This report summarizes the ELIXIR Toxicology Community workshop on Systems Biology Models for Toxicology, held on 11–12 September 2025 in Athens, Greece. The workshop tookplace under the INTOXICOM Implementation Study workshop series (Integrating the toxicology community into ELIXIR 2024) and aimed to strengthen connections between systems biologyand toxicology by bridging ELIXIR resources with systems toxicology modelling approaches usedfor chemical risk assessment. The workshop explored the role of qualitative and quantitative exposure–health outcome models, including (quantitative) Adverse Outcome Pathways ((q)-AOPs), AOP networks, and mechanistic toxicology models. Participants examined two usecases focused on neurotoxicity and endocrine disruption, discussing how ELIXIR tools, platforms,core data resources, and modelling environments can support them. The workshop concluded with a discussion on a roadmap for integrating ELIXIR systems biology infrastructures and tools into applied systems toxicology. This report documents the presentations, discussions, and practical results that contribute to Deliverables of INTOXICOM WP5.